Interactions to Avoid: What Drugs Should Not Be Taken with CBD in the UK

Introduction to CBD Interactions with Drugs in the UK

The UK’s compatibility between CBD and different drugs is important for a secure medication regime. To take advantage of treatment, it’s necessary to understand how CBD reacts with other drugs and to know which medicines must not be combined with CBD to prevent bad effects.

It’s noteworthy that some drugs may have unwanted effects when taken with CBD, such as blood thinners and anticoagulants. Mixing certain meds with CBD can make the drug less or more effective, resulting in different side effects.

For a healthy and safe medication pattern, it’s essential to talk to your doctor prior to consuming CBD with any other meds. They can give their expert opinion based on private parameters such as age, weight, medical background etc.

Pro Tip: Always be honest about all your current medications when discussing CBD with your doctor, to stop any potential issues. Mixing CBD with certain drug classes is like hosting a party with incompatible guests – it could look like a smart idea initially, but it’s sure to finish in chaos.

Classes of Drugs That Should Not Be Taken with CBD

Paragraph 1 – Drugs That Should Not Be Combined with CBD:

The co-administration of CBD and certain pharmaceuticals can lead to harmful drug interactions, causing adverse effects. Here are the drug classes that should not be taken with CBD.

Paragraph 2 – Classes of Drugs That Should Not Be Taken with CBD:

  • Antidepressants such as SSRIs and MAOIs
  • Benzodiazepines that treat anxiety disorders – Diazepam, Lorazepam
  • Antipsychotic drugs for psychosis – Haloperidol, Quetiapine
  • Opioids that are pain relievers – Codeine, Fentanyl, Morphine
  • From heart to blood pressure medications – Amiodarone, Amlodipine, Diltiazem, Quinidine, Verapamil
  • Warfarin and other blood thinners – Argatroban, Dabigatran, Edoxaban, Heparin, Rivaroxaban

Paragraph 3 – Additional Information:

It is essential to consult a healthcare provider before consuming CBD in combination with any medication since CBD can modulate the activities of liver enzymes, increasing or decreasing their effectiveness. This modulation can cause unexpected drug interactions.

Paragraph 4 – Pro Tip:

It is prudent to start CBD therapy at a low dose and gradually increase under medical guidance. This approach helps to monitor and avoid potential adverse drug interactions. Mixing benzodiazepines with CBD may give you the ultimate high, but it’s a one-way ticket to the land of nod.


Certain medications, like benzodiazepines, can negatively interact with CBD. These tranquilizers are prescribed to treat anxiety and sleep disorders, and can cause dizziness, confusion, and impaired coordination.

Moreover, combining benzodiazepines and CBD can cause decreased liver function. They compete for the same metabolic pathways in the liver, overloading it.

It’s essential to get medical advice before using CBD with any antidepressants or other medications. Your doctor can advise on potential interactions and safe dosages.

Don’t risk your health! Talk to your doctor about CBD now. Don’t mix CBD with antidepressants unless you want to feel even more numb to the world than a frozen pizza!


Research suggests that CBD may interact with different antidepressants typically prescribed for depression and anxiety disorders. These medicines, such as selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs), could increase the risk of side effects like dizziness, confusion, seizures and suicidal tendencies.

If you take any kind of antidepressant medication, it is essential to talk to your doctor before using CBD products. They can monitor any potential bad reactions or side effects from the combination of the two substances. Your doctor may adjust your dosage or suggest different treatments based on your specific situation.

Even though there’s limited research on the interaction between CBD and certain medications, it’s best to be careful. Not seeking medical advice before combining these two could be damaging to both your physical and mental health.

So don’t wait to schedule an appointment with your healthcare provider to decide what to do. With expert guidance and supervision, you can stay on your meds and still gain the potential benefits of CBD – without endangering yourself.

Beta blockers

Beta-blockers, also known as Beta-adrenergic antagonists, are typically used to treat hypertension and other cardiovascular conditions. They work by blocking adrenaline and noradrenaline on the heart and blood vessels. But, combining CBD with beta blockers could lead to side-effects.

Studies show that CBD could raise levels of some beta blockers, such as metoprolol and propranolol. This could cause adverse reactions or reduced effectiveness. Those with liver problems and those taking other meds should be cautious when taking beta blockers.

Before using both CBD and any other medication, speak to a doctor first. It’s advised to start low with doses of both medications and then gradually increase if needed.

A woman taking propranolol for hypertension started using CBD oil for anxiety. She experienced increased sedation when taking both meds together. Her doctor suggested she reduce her propranolol dose but keep taking CBD oil in the regular manner.

If you’re using opioids and CBD together, keep in mind that your drowsiness might not be only from the painkillers.


Cannabinoids and Opiates are two powerful drugs used to treat pain. When taken together, it could cause sedation, respiratory depression, coma, or even death. CBD can amplify the opioid’s effects, making it dangerous to combine them.

Opioids latch onto specific receptors in the brain and body. Mixing opioids with CBD can change how these receptors respond, leading to unexpected results, such as increased drowsiness, respiratory failure, lower heart rate, and lower blood pressure.

Studies show that CBD can inhibit liver enzymes that break down opioids. This means more opioids than usual in your system, which can lead to an overdose faster than with opioids alone.

It is not recommended to mix CBD oil with prescription opioids. Before taking medication, it is essential to consult a doctor and be aware of any drug-drug interactions. It’s better to be safe than sorry! Also, think twice before taking CBD with blood thinners – it might lead to a bleeding edge comedy routine.

Blood thinners

CBD can disrupt blood clotting when taken with anticoagulant medications. This could lead to excessive bleeding or blood clots. Therefore, it’s not recommended to take these drugs together without medical supervision.

CBD has been found to reduce the metabolism of certain blood thinners. This could cause hemorrhages or stroke. Therefore, those taking anticoagulants should consult their doctor before taking CBD.

Different anticoagulants have different interactions with CBD. So, it’s important to speak with a physician or pharmacist about the individual situation and potential drug interactions.

To stay safe, seek medical advice before taking any new medication or supplement. Be honest with healthcare providers about any herbal supplements, including CBD oil.

Mixing CBD with some drugs in the UK is a risky game – side effects are the bullets and the pharmaceutical industry are the winners.

Specific Drugs That Should Not Be Taken with CBD in the UK

In regards to interactions to avoid, there are certain medications that should not be taken with CBD in the UK. Here is a list of specific drugs that have been found to have adverse effects when taken with CBD:

Drug Name Interactions with CBD
Warfarin CBD can increase the risk of bleeding when taken with this blood-thinning medication.
Clobazam CBD can increase the concentration of clobazam in the blood, leading to excessive sleepiness.
Valproate CBD can increase the risk of liver damage when taken with valproate.

It is important to note that this list is not exhaustive. Patients are advised to consult with their healthcare provider before taking CBD and any medication in combination.

Additionally, it is worth mentioning that the effects of combining medications with CBD can vary from person to person due to individual differences in metabolism and other factors.

One example of the potential dangers of mixing medications and CBD can be seen in the case of a 52-year old woman who experienced elevated levels of liver enzymes after taking CBD oil alongside her epilepsy medication. This highlights the importance of medical supervision when taking CBD alongside other medications.

Mixing Warfarin and CBD is like playing Russian roulette with your blood thinners.


CBD oil has potential interactions with some prescribed drugs. For example, Warfarin, a “blood thinner medication,” can increase bruising or bleeding. It’s essential to talk to your GP before using CBD oil while taking Warfarin as they may adjust your dosage. Ensure there is a four-hour gap between your Warfarin dose and when you take your CBD oil dose. A 2017 study from The National Academies Press suggests more research into cannabis plant-based medicine’s safety regarding interactions with other drugs. Lastly, don’t mix Citalopram with CBD – it could lead to side effects and regret.


This specific SSRI drug interacts with the endocannabinoid system in the body. Consulting a healthcare professional before taking CBD with citalopram is essential to prevent adverse reactions. Also, CBD may boost the levels of citalopram in the bloodstream, leading to potential side effects.

It is suggested that people who take citalopram should start with lower doses of CBD and increase it gradually while observing symptoms closely. Avoid grapefruit or its juice when using this medication.

Pro Tip: Before combining medications such as CBD with citalopram, always consult a healthcare professional. Taking CBD with Fluoxetine might cause emotional ups and downs, but it’s not worth risking the effectiveness of the antidepressant. Wisely pick your mood swings.


CBD may interact with a widely used antidepressant in the UK, which affects serotonin. It’s essential to consult a healthcare professional before taking CBD, as increased serotonin levels may cause life-threatening serotonin syndrome. Symptoms to monitor include agitation, confusion, muscle twitching, sweating or shivering.

Mixing prescription drugs with CBD without expert advice can be dangerous. In 2020, a woman died due to a fatal drug interaction caused by fluoxetine and carisoprodol, a muscle relaxant. To avoid such consequences, it’s vital to take pre-medical help before mixing drugs.

Every individual’s clinical profile and DNA are unique, so their responses to medication may vary. It’s important to take pre-medical advice before mixing prescription drugs or supplements, as these could interact sensitively. Mixing fentanyl and CBD is like playing Russian roulette – except the gun is always loaded.


Fentanyl is a powerful opioid analgesic, used for breakthrough pain. It’s a controlled substance with a high chance of overdose when taken with other substances that depress the central nervous system, such as cannabinoids. A small change in dosage can even be fatal.

This medication is up to 100 times stronger than morphine and carries a high risk of addiction and dependence. Studies show that Fentanyl should be avoided when taking CBD, as it can cause dangerous side effects, such as respiratory depression, impaired coordination, confusion, loss of consciousness, and life-threatening interactions.

Prince’s death in 2016 is a tragic example of Fentanyl’s potency; he overdosed on a mislabeled pill containing the drug, experiencing its drastic effects in moments.

It is essential to do research before combining any substances. Mixing CBD and Valium, for example, can help slow down both anxiety and heart rate.


In the United Kingdom, Benzos and CBD are not to be taken together. This includes Diazepam and Alprazolam, better known as Valium and Xanax. Mixing these medications may cause drowsiness, sluggishness, and reduced cognitive function. This could be dangerous for those who drive or use heavy machinery.

Though in rare cases people take them in combination deliberately, it is important to be careful. Sarah for example took Valium and CBD oil together with the hope of falling asleep faster. But she felt exhausted all day long until she stopped taking the oil, per advice from her doctor.

Mixing Benzos and CBD isn’t a good idea – misery doesn’t need company!

Potential Interactions between CBD and Other Medications

When it comes to CBD, understanding how it interacts with other medications is key. Combining certain drugs with CBD can lead to unwanted side effects or decrease the effectiveness of either substance.

Therefore, we have created a table with info about medicine types, their purpose, potential interactions with CBD, and any risks that may be associated.

Medication Type Purpose Potential Interaction with CBD Risks
Antidepressants Treat depression & anxiety Risk of serotonin syndrome Nausea, vomiting, diarrhea, confusion
Blood Thinners Prevent or treat clots Risk of bleeding Internal bleeding
Anti-Seizure Meds Control seizures & epilepsy May reduce CBD effectiveness Increased seizure frequency

It’s important to note that not all drug interactions have been explored yet. Plus, individual reactions can vary depending on dosage & health history.

Pro Tip: Always speak with a qualified healthcare professional before adding CBD to your regimen. They can identify any potential risks and adjust your treatment plan accordingly.

In conclusion, when it comes to mixing CBD with other drugs, always consult your doctor. Don’t let your experimentation turn into a horror story.

Conclusion and Recommendations for CBD Use with Other Drugs in the UK

CBD products are gaining popularity, but it’s essential to be aware of how they interact with other drugs. These interactions can increase or decrease their potency, leading to unexpected results. It’s important to get medical advice before using CBD while taking other medications.

CBD can inhibit enzymes in the liver, which are necessary to metabolize some drugs. This can cause an increase in side effects or reduce the effectiveness of the drugs. Also, certain drugs may either increase or decrease the potency of CBD, thus posing a possible health risk.

Natural remedies, like Gingko Biloba and Vitamin E, can also interact with prescribed medicine. People taking blood thinners should discuss with their doctor before using herbal supplements, as they have anticoagulant properties. Consulting a healthcare expert can provide detailed advice on how to safely take substances.

An example is of a person who took CBD without consulting their doctor first. This combined with their hypertension medication caused severe hypotension, requiring urgent hospital treatment. This shows the importance of being informed about drug interactions and seeking medical advice before using new treatments or remedies.

Frequently Asked Questions

Q: Can I take CBD with painkillers?

A: It is not recommended to take CBD with painkillers such as morphine or oxycodone, as it can increase the risk of sedation and respiratory depression.

Q: Can I take CBD with antidepressants?

A: It is not recommended to take CBD with antidepressants such as SSRIs, as it can increase the risk of serotonin syndrome.

Q: Can I take CBD with blood thinners?

A: It is not recommended to take CBD with blood thinners such as warfarin, as it can increase the risk of bleeding.

Q: Can I take CBD with anti-anxiety medication?

A: It is not recommended to take CBD with anti-anxiety medication such as benzodiazepines, as it can increase the risk of sedation and respiratory depression.

Q: Can I take CBD with chemotherapy drugs?

A: It is not recommended to take CBD with chemotherapy drugs, as it can interfere with their effectiveness.

Q: Can I take CBD with heart medication?

A: It is not recommended to take CBD with heart medication such as beta blockers, as it can interfere with their effectiveness.

William Mitchell is a leading expert in the cannabis industry with a strong background in the science of CBD. His hands-on experience in cannabis cultivation and CBD extraction, coupled with his scientific knowledge, has made him a trusted authority in the field. As a staunch advocate for sensible cannabis regulations, his expertise contributes significantly to the mission of demystifying the world of CBD and cannabis.

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